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Triamterene is less soluble in solutions with a pH less than 6. Triamterene is combined with hydrochlorothiazide to treat high blood pressure. Seek medical attention right away if any of these SEVERE side effects occur when using Triamterene:Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dry mouth; excessive thirst; slow or irregular heart rate; unusual muscle weakness; unusual tiredness; vomiting; yellowing of the skin or eyes. Arrhythmias have been associated with HCTZ-induced hypokalemia; hypokalemia is much less likely with the addition of triamterene. {51} {52} Amiloride and triamterene have a direct inhibitory effect on the entry of sodium into the cells, while spironolactone competitively inhibits the action of aldosterone. It is not known whether amiloride or triamterene passes into breast milk.

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